Botulinum toxin and neuromotor rehabilitation: An integrated approach to idiopathic cervical dystonia
Identifieur interne : 003559 ( Main/Exploration ); précédent : 003558; suivant : 003560Botulinum toxin and neuromotor rehabilitation: An integrated approach to idiopathic cervical dystonia
Auteurs : Cristina Tassorelli [Italie] ; Francesca Mancini [Italie] ; Laura Balloni [Italie] ; Claudio Pacchetti [Italie] ; Giorgio Sandrini [Italie] ; Giuseppe Nappi [Italie] ; Emilia Martignoni [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-12.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Activities of Daily Living, Aged, Analysis of Variance, Biofeedback, Bontoxilysin, Botulinum Toxins, Type A (therapeutic use), Cross-Over Studies, Double-Blind Method, Dystonia, Electromyography (methods), Female, Humans, Idiopathic, Injections, Intramuscular, Male, Middle Aged, Nervous system diseases, Neuromuscular Agents (therapeutic use), Pain Measurement, Physical Therapy Specialty (methods), Physiotherapy, Rehabilitation, Surgical approach, Time Factors, Torticollis (drug therapy), Torticollis (rehabilitation), Treatment Outcome, biofeedback, botulinum toxin, cervical dystonia, physiotherapy.
- MESH :
- chemical , therapeutic use : Botulinum Toxins, Type A, Neuromuscular Agents.
- drug therapy : Torticollis.
- methods : Electromyography, Physical Therapy Specialty.
- rehabilitation : Torticollis.
- Activities of Daily Living, Aged, Analysis of Variance, Cross-Over Studies, Double-Blind Method, Female, Humans, Injections, Intramuscular, Male, Middle Aged, Pain Measurement, Time Factors, Treatment Outcome.
Abstract
Currently, the best treatment option for idiopathic cervical dystonia (ICD) is injection of botulinum toxin (BTX) into the affected muscles, whereas rehabilitative approaches have given disappointing results. We evaluated whether the association of an ad hoc rehabilitative program may improve the clinical efficacy of BTX treatment in a single‐center, cross‐over, controlled study. Forty patients with ICD were randomly assigned to two different treatment groups: (1) BTX type A (BTX‐A) plus a specific program of physical therapy (BTX‐PT) or (2) BTX‐A alone (BTX‐0). Patients in the BTX‐PT group showed a longer duration of the clinical benefit (118.8 vs. 99.1 days) and needed a lower dose of BTX at reinjection (284.5 vs. 325.5 units). In addition, they showed more marked reductions in their disability in activities of daily living (−9.7 vs. −4.85 points) and subjective pain (−13.35 vs. 6.95 points) scores. Association of BTX‐A therapy with a specific program of physical therapy may improve ICD treatment outcome. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21145
Affiliations:
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Mondino Institute of Neurology” Foundation</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>University A, Avogadro, Novara and Maugeri Foundation, Veruno Institute</wicri:regionArea><wicri:noRegion>Veruno Institute</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-12">2006-12</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2240">2240</biblScope><biblScope unit="page" to="2243">2243</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">4BAD61A259E310C1C6DB28DF908A20CA532FEBB8</idno><idno type="DOI">10.1002/mds.21145</idno><idno type="ArticleID">MDS21145</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term><term>Aged</term><term>Analysis of Variance</term><term>Biofeedback</term><term>Bontoxilysin</term><term>Botulinum Toxins, Type A (therapeutic use)</term><term>Cross-Over Studies</term><term>Double-Blind Method</term><term>Dystonia</term><term>Electromyography (methods)</term><term>Female</term><term>Humans</term><term>Idiopathic</term><term>Injections, Intramuscular</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Neuromuscular Agents (therapeutic use)</term><term>Pain Measurement</term><term>Physical Therapy Specialty (methods)</term><term>Physiotherapy</term><term>Rehabilitation</term><term>Surgical approach</term><term>Time Factors</term><term>Torticollis (drug therapy)</term><term>Torticollis (rehabilitation)</term><term>Treatment Outcome</term><term>biofeedback</term><term>botulinum toxin</term><term>cervical dystonia</term><term>physiotherapy</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Botulinum Toxins, Type A</term><term>Neuromuscular Agents</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Torticollis</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electromyography</term><term>Physical Therapy Specialty</term></keywords><keywords scheme="MESH" qualifier="rehabilitation" xml:lang="en"><term>Torticollis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term><term>Aged</term><term>Analysis of Variance</term><term>Cross-Over Studies</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Injections, Intramuscular</term><term>Male</term><term>Middle Aged</term><term>Pain Measurement</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Biofeedback</term><term>Bontoxilysin</term><term>Dystonie</term><term>Idiopathique</term><term>Physiothérapie</term><term>Réhabilitation</term><term>Système nerveux pathologie</term><term>Voie abord</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Currently, the best treatment option for idiopathic cervical dystonia (ICD) is injection of botulinum toxin (BTX) into the affected muscles, whereas rehabilitative approaches have given disappointing results. We evaluated whether the association of an ad hoc rehabilitative program may improve the clinical efficacy of BTX treatment in a single‐center, cross‐over, controlled study. Forty patients with ICD were randomly assigned to two different treatment groups: (1) BTX type A (BTX‐A) plus a specific program of physical therapy (BTX‐PT) or (2) BTX‐A alone (BTX‐0). Patients in the BTX‐PT group showed a longer duration of the clinical benefit (118.8 vs. 99.1 days) and needed a lower dose of BTX at reinjection (284.5 vs. 325.5 units). In addition, they showed more marked reductions in their disability in activities of daily living (−9.7 vs. −4.85 points) and subjective pain (−13.35 vs. 6.95 points) scores. Association of BTX‐A therapy with a specific program of physical therapy may improve ICD treatment outcome. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Tassorelli, Cristina" sort="Tassorelli, Cristina" uniqKey="Tassorelli C" first="Cristina" last="Tassorelli">Cristina Tassorelli</name></noRegion><name sortKey="Balloni, Laura" sort="Balloni, Laura" uniqKey="Balloni L" first="Laura" last="Balloni">Laura Balloni</name><name sortKey="Mancini, Francesca" sort="Mancini, Francesca" uniqKey="Mancini F" first="Francesca" last="Mancini">Francesca Mancini</name><name sortKey="Martignoni, Emilia" sort="Martignoni, Emilia" uniqKey="Martignoni E" first="Emilia" last="Martignoni">Emilia Martignoni</name><name sortKey="Martignoni, Emilia" sort="Martignoni, Emilia" uniqKey="Martignoni E" first="Emilia" last="Martignoni">Emilia Martignoni</name><name sortKey="Nappi, Giuseppe" sort="Nappi, Giuseppe" uniqKey="Nappi G" first="Giuseppe" last="Nappi">Giuseppe Nappi</name><name sortKey="Nappi, Giuseppe" sort="Nappi, Giuseppe" uniqKey="Nappi G" first="Giuseppe" last="Nappi">Giuseppe Nappi</name><name sortKey="Nappi, Giuseppe" sort="Nappi, Giuseppe" uniqKey="Nappi G" first="Giuseppe" last="Nappi">Giuseppe Nappi</name><name sortKey="Pacchetti, Claudio" sort="Pacchetti, Claudio" uniqKey="Pacchetti C" first="Claudio" last="Pacchetti">Claudio Pacchetti</name><name sortKey="Sandrini, Giorgio" sort="Sandrini, Giorgio" uniqKey="Sandrini G" first="Giorgio" last="Sandrini">Giorgio Sandrini</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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